The laboratory test results are NOT to be interpreted as results of a "stand-alone" test. Medications that suppress platelet formation (such as chemotherapy drugs).With hypersplenism, platelets are often "sequestered" in the spleen. Splenomegaly (an enlargement of the spleen).Bone marrow failure (older platelets are smaller, so the MPV is low if the bone marrow isn't producing as many).A low MPV with a normal platelet count is common with chronic kidney failure. A low MPV with a high platelet count often signifies an infection, inflammation, or cancer. A low MPV with a low platelet count can point towards disorders affecting the bone marrow that slow down or decrease the production of platelets, such as a condition called aplastic anemia. Possible causes of a low MPV can also vary depending on the platelet count.Causes of Low Mean Platelet Volume (MPV).Pre-eclampsia (toxemia of pregnancy) and HELLP syndrome.Bone marrow stimulating drugs, such as erythropoietin or thrombopoietin.Bernard-Soulier Disease (giant platelet syndrome).
#Mpv on blood test skin
(The term petechiae refers to small red marks on the skin (small bruises) which don't blanch when you press on them.) Purpura is the medical term for a bruise, usually a fairly large bruise. The root word "thrombo" refers to clot (the function of platelets) and "penia" refers to deficiency, so thrombocytopenia refers to a deficiency of platelets. It is doctor lingo for "we don't have a clue" why it occurs. Idiopathic is a term used to describe a condition of unknown cause. The condition idiopathic thrombocytopenic purpura has a long name, but looking at each of the terms in ITP makes this easier to understand. Idiopathic thrombocytopenic purpura (ITP): ITP is a condition in which the immune system destroys platelets.In response, your bone marrow releases more of the young, larger platelets, and your MPV rises.Įvaluating a high MPV is most helpful in determining the cause of a low platelet count, and the most common cause is "destruction," or the platelets being destroyed in some way, such as by antibodies you produce (see ITP below).Ī high MPV with a high platelet count, in contrast, is often due to primary or essential thrombocytosis (a condition in which the body produces too many platelets, often due to a genetic mutation), or cancer.Ī high MPV with a normal platelet count suggests conditions such as hyperthyroidism, or chronic myelogenous leukemia.Ĭonditions that may cause an elevated MPV include : If you have had a procedure such as major surgery, your body is using up platelets to repair the cuts to the blood vessels. A CBC reveals important information about the number of different blood cells in the body.Ĭauses of a High Mean Platelet Volume (MPV)Ī high MPV is usually a sign that there are more young platelets circulating in your bloodstream. The mean platelet volume (MPV) blood test is typically part of a complete blood count (CBC) test. High or low platelet levels can be a sign of a severe condition. Platelets help the blood heal wounds and prevent excessive bleeding. Mean platelet blood volume is a blood test that measures the average number of platelets in the blood. This poses a much higher risk of clotting or bleeding complications than does reactive thrombocytosis.Why test for Mean Platelet Volume (MPV) at Symbion VIP Diagnostics, Ahmedabad ? Your bone marrow produces too many of the cells that form platelets and these platelets are often abnormal. The cause of this disorder is unclear but it often appears to be connected to mutations in a variety of genes. Inflammatory disorders, such as rheumatoid arthritis, sarcoidosis or inflammatory bowel disease.Hemolytic anemia - a type of anemia in which your body destroys red blood cells faster than it produces them, often due to certain blood diseases or autoimmune disorders.It’s caused by an underlying medical problem, such as: This is the more common type of thrombocytosis. Thrombocytosis occurs when your body produces too many platelets. Platelets stick together, helping blood to form a clot that stops bleeding when you damage a blood vessel, such as when you cut yourself. Bone marrow - spongy tissue inside your bones - contains stem cells that can become red blood cells, white blood cells or platelets.
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